Dehal, S S <br/><br/>
Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jun 1999 
 - 681-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0090-9556 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Biotransformation<br/>Catechols--metabolism<br/>Cytochrome P-450 CYP2D6--biosynthesis<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme System--biosynthesis<br/>Estrogen Antagonists--pharmacokinetics<br/>Humans<br/>Hydroxylation<br/>In Vitro Techniques<br/>Liver--drug effects<br/>Mixed Function Oxygenases--biosynthesis<br/>Pentobarbital--pharmacology<br/>Protein Binding<br/>Rats<br/>Rats, Sprague-Dawley<br/>Tamoxifen--analogs & derivatives