Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2. [electronic resource]
- Biochemical and biophysical research communications May 1999
- 97-102 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-291X
10.1006/bbrc.1999.0715 doi
Activins Animals Bone Development--drug effects Bone Marrow Cells Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins--pharmacology Carrier Proteins--metabolism Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors--pharmacology Gene Expression Regulation, Developmental Indomethacin--pharmacology Inhibins--pharmacology Interleukin-1--pharmacology Isoenzymes--metabolism Membrane Glycoproteins--metabolism Mice Mice, Inbred Strains Nitrobenzenes--pharmacology Osteoclasts--physiology Prostaglandin-Endoperoxide Synthases--metabolism RANK Ligand RNA, Messenger--metabolism Receptor Activator of Nuclear Factor-kappa B Sulfonamides--pharmacology Transforming Growth Factor beta--pharmacology Up-Regulation--genetics