TY - GEN AU - Zhang,M AU - Bailey,D L AU - Bastian,J A AU - Briggs,S L AU - Chirgadze,N Y AU - Clawson,D K AU - Denney,M L AU - Gifford-Moore,D S AU - Harper,R W AU - Johnson,L M AU - Klimkowski,V J AU - Kohn,T J AU - Lin,H S AU - McCowan,J R AU - Richett,M E AU - Sall,D J AU - Smith,A J AU - Smith,G F AU - Snyder,D W AU - Takeuchi,K AU - Utterback,B G AU - Yan,S C TI - Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy SN - 0960-894X PY - 1999///0604 KW - Animals KW - Anticoagulants KW - chemistry KW - Binding Sites KW - Crystallography, X-Ray KW - Disease Models, Animal KW - Humans KW - Models, Molecular KW - Rats KW - Structure-Activity Relationship KW - Thiophenes KW - Thrombin KW - antagonists & inhibitors KW - Thrombosis KW - drug therapy N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/s0960-894x(99)00074-8 ER -