A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production. [electronic resource]
- Cellular immunology Mar 1999
- 87-95 p. digital
Publication Type: Journal Article
0008-8749
10.1006/cimm.1998.1448 doi
CD28 Antigens--physiology Calcium-Calmodulin-Dependent Protein Kinases--antagonists & inhibitors Cells, Cultured Cytokines--biosynthesis Dose-Response Relationship, Drug Humans Imidazoles--pharmacology Interferon-gamma--biosynthesis Interleukin-10--biosynthesis Interleukin-2--biosynthesis Lymphocyte Activation--drug effects Mitogen-Activated Protein Kinases Pyridines--pharmacology RNA, Messenger--analysis T-Lymphocytes--metabolism p38 Mitogen-Activated Protein Kinases