Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. [electronic resource]
- The Journal of infectious diseases Apr 1999
- 939-44 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1899
10.1086/314659 doi
Calcium-Calmodulin-Dependent Protein Kinases--antagonists & inhibitors Cells, Cultured Dose-Response Relationship, Drug Flavonoids--pharmacology Humans Imidazoles--pharmacology Interferon-gamma--pharmacology Lipopolysaccharides--pharmacology Macrophages Mitogen-Activated Protein Kinases Nitric Oxide--biosynthesis Nitric Oxide Synthase--antagonists & inhibitors Nitric Oxide Synthase Type II Pyridines--pharmacology Tumor Necrosis Factor-alpha--antagonists & inhibitors p38 Mitogen-Activated Protein Kinases