TY  - GEN
AU  - Groneberg,R D
AU  - Burns,C J
AU  - Morrissette,M M
AU  - Ullrich,J W
AU  - Morris,R L
AU  - Darnbrough,S
AU  - Djuric,S W
AU  - Condon,S M
AU  - McGeehan,G M
AU  - Labaudiniere,R
AU  - Neuenschwander,K
AU  - Scotese,A C
AU  - Kline,J A
TI  - Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template
SN  - 0022-2623
PY  - 1999///0316
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Fibroblasts
KW  - enzymology
KW  - Gelatinases
KW  - Guinea Pigs
KW  - Hydroxamic Acids
KW  - chemical synthesis
KW  - Macrophages
KW  - Matrix Metalloproteinase 1
KW  - Matrix Metalloproteinase 2
KW  - Matrix Metalloproteinase Inhibitors
KW  - Metalloendopeptidases
KW  - Phosphodiesterase Inhibitors
KW  - Protease Inhibitors
KW  - Structure-Activity Relationship
KW  - Sulfones
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm980567e
ER  -