TY - GEN AU - Zhang,J G AU - Farley,A AU - Nicholson,S E AU - Willson,T A AU - Zugaro,L M AU - Simpson,R J AU - Moritz,R L AU - Cary,D AU - Richardson,R AU - Hausmann,G AU - Kile,B T AU - Kile,B J AU - Kent,S B AU - Alexander,W S AU - Metcalf,D AU - Hilton,D J AU - Nicola,N A AU - Baca,M TI - The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation SN - 0027-8424 PY - 1999///0415 KW - Amino Acid Sequence KW - Animals KW - Binding Sites KW - Carrier Proteins KW - chemistry KW - Cell Line KW - Cysteine Endopeptidases KW - metabolism KW - Cytokines KW - physiology KW - Elongin KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Mice KW - Models, Chemical KW - Molecular Sequence Data KW - Multienzyme Complexes KW - Proteasome Endopeptidase Complex KW - Protein-Tyrosine Kinases KW - Proteins KW - Recombinant Fusion Proteins KW - biosynthesis KW - Recombinant Proteins KW - Repressor Proteins KW - Signal Transduction KW - Suppressor of Cytokine Signaling 1 Protein KW - Suppressor of Cytokine Signaling 3 Protein KW - Suppressor of Cytokine Signaling Proteins KW - Transcription Factors KW - Transfection KW - Tumor Cells, Cultured KW - src Homology Domains N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1073/pnas.96.5.2071 ER -