G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation. [electronic resource]
Producer: 19990325Description: 1427-32 p. digitalISSN:- 0027-8424
- Amino Acid Substitution
- Apoptosis
- Arginine
- Breast Neoplasms
- Cell Cycle
- Cell Division
- Cell Nucleus -- physiology
- Cell Transformation, Neoplastic
- DNA-Binding Proteins -- genetics
- Female
- G1 Phase
- Genes, Reporter
- Genes, Tumor Suppressor
- Humans
- In Situ Nick-End Labeling
- Kinetics
- Mutagenesis, Site-Directed
- Phenotype
- Recombinant Fusion Proteins -- biosynthesis
- Signal Transduction
- Smad4 Protein
- Threonine
- Trans-Activators -- genetics
- Transfection
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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