Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme. [electronic resource]
Producer: 19990223Description: 1633-42 p. digitalISSN:- 0006-2960
- Amino Acid Sequence
- Animals
- Cats
- DNA, Viral -- biosynthesis
- Dideoxynucleotides
- Dimerization
- Enzyme Activation -- genetics
- Enzyme Stability -- genetics
- Genetic Vectors -- chemical synthesis
- HIV Reverse Transcriptase -- antagonists & inhibitors
- Humans
- Immunodeficiency Virus, Feline -- enzymology
- Molecular Sequence Data
- Nevirapine -- pharmacology
- Peptide Fragments -- antagonists & inhibitors
- Protein Processing, Post-Translational -- genetics
- RNA-Directed DNA Polymerase -- chemistry
- Recombinant Fusion Proteins -- antagonists & inhibitors
- Reverse Transcriptase Inhibitors -- pharmacology
- Ribonuclease H -- chemistry
- Structure-Activity Relationship
- Thymine Nucleotides -- pharmacology
- Zidovudine -- analogs & derivatives
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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