The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. [electronic resource]
Producer: 19990225Description: 270-1 p. digitalISSN:- 0077-8923
- Animals
- Body Temperature Regulation -- drug effects
- CHO Cells
- Cerebral Cortex -- drug effects
- Cricetinae
- Dentate Gyrus -- drug effects
- Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism
- Guinea Pigs
- Humans
- Oxadiazoles -- chemistry
- Piperazines -- chemistry
- Piperidones -- chemistry
- Receptor, Serotonin, 5-HT1B
- Receptors, Serotonin -- drug effects
- Recombinant Proteins -- drug effects
- Serotonin -- metabolism
- Serotonin Antagonists -- pharmacology
- Spiro Compounds -- chemistry
- Sumatriptan -- pharmacology
- Transfection
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Publication Type: Journal Article
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