Three residues predicted by molecular modeling to interact with the purine moiety alter ligand binding and channel gating in cyclic nucleotide-gated channels. [electronic resource]
Producer: 19990112Description: 17239-52 p. digitalISSN:- 0006-2960
- Amino Acid Substitution -- genetics
- Amino Acids -- metabolism
- Animals
- Aspartic Acid -- genetics
- Cattle
- Cyclic GMP -- genetics
- Cyclic Nucleotide-Gated Cation Channels
- Evoked Potentials -- drug effects
- Ion Channels -- genetics
- Ligands
- Lysine -- genetics
- Models, Molecular
- Mutagenesis, Site-Directed
- Nickel -- pharmacology
- Patch-Clamp Techniques
- Phenylalanine -- genetics
- Protein Binding -- drug effects
- Protons
- Purine Nucleotides -- metabolism
- Rod Cell Outer Segment -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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