Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). [electronic resource]
Producer: 19990121Description: 5198-218 p. digitalISSN:- 0022-2623
- Administration, Oral
- Animals
- Aorta, Thoracic -- drug effects
- Blood Pressure -- drug effects
- Carotid Arteries -- drug effects
- Cerebellum -- drug effects
- Endothelin Receptor Antagonists
- Endothelin-1 -- pharmacology
- Female
- In Vitro Techniques
- Injections, Intravenous
- Isoxazoles -- administration & dosage
- Macaca fascicularis
- Male
- Rabbits
- Radioligand Assay
- Rats
- Receptor, Endothelin A
- Structure-Activity Relationship
- Sulfonamides -- administration & dosage
- Vasoconstriction -- drug effects
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Publication Type: Journal Article
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