Regulation of steroidogenesis by insulin-like growth factors (IGFs) in adult human adrenocortical cells: IGF-I and, more potently, IGF-II preferentially enhance androgen biosynthesis through interaction with the IGF-I receptor and IGF-binding proteins. [electronic resource]
Producer: 19981216Description: 409-17 p. digitalISSN:- 0022-0795
- Adrenal Cortex -- drug effects
- Adrenocorticotropic Hormone -- pharmacology
- Adult
- Androgens -- biosynthesis
- Blotting, Western
- Cells, Cultured
- Cyclic AMP -- biosynthesis
- Dehydroepiandrosterone Sulfate -- metabolism
- Dose-Response Relationship, Drug
- Humans
- Hydrocortisone -- biosynthesis
- Insulin-Like Growth Factor Binding Proteins -- metabolism
- Insulin-Like Growth Factor I -- pharmacology
- Insulin-Like Growth Factor II -- pharmacology
- Recombinant Proteins -- pharmacology
- Somatomedins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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