Quinoxaline chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity and enzymatic inhibitory activity against dihydrofolate reductase and thymidylate synthase. [electronic resource]
Producer: 19981228Description: 480-93 p. digitalISSN:- 0014-827X
- Animals
- Antineoplastic Agents -- chemistry
- Cattle
- Enzyme Inhibitors -- chemistry
- Folic Acid Antagonists -- pharmacology
- Humans
- Molecular Structure
- Quinoxalines -- chemical synthesis
- Rats
- Structure-Activity Relationship
- Thymidylate Synthase -- antagonists & inhibitors
- Tumor Cells, Cultured -- drug effects
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Publication Type: Comparative Study; Journal Article
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