Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3. [electronic resource]
Producer: 19990122Description: 465-70 p. digitalISSN:- 8756-3282
- 24,25-Dihydroxyvitamin D 3 -- pharmacology
- Alkaline Phosphatase -- metabolism
- Animals
- Calcitriol -- pharmacology
- Cell Differentiation -- drug effects
- Cells, Cultured
- Chondrocytes -- cytology
- Collagen -- metabolism
- Dose-Response Relationship, Drug
- Down-Regulation -- physiology
- Drug Synergism
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Transforming Growth Factor beta -- pharmacology
- Up-Regulation -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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