Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53. [electronic resource]
Producer: 19981116Description: 2393-402 p. digitalISSN:- 0950-9232
- Antineoplastic Agents -- pharmacology
- Breast -- metabolism
- Breast Neoplasms -- metabolism
- CDC2-CDC28 Kinases
- Cell Cycle Proteins
- Cyclin D3
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinases -- metabolism
- Cyclins -- metabolism
- Female
- G1 Phase -- drug effects
- Humans
- Lovastatin -- pharmacology
- Microtubule-Associated Proteins -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins
- Retinoblastoma Protein -- metabolism
- Tumor Cells, Cultured -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Tumor Suppressor Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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