Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. [electronic resource]
Producer: 19981221Description: 3804-16 p. digitalISSN:- 0006-4971
- Animals
- Antineoplastic Agents -- administration & dosage
- Apoptosis -- drug effects
- Caspase 3
- Caspases -- physiology
- Cell Cycle Proteins
- Chromosomes, Human, Pair 17 -- genetics
- Cyclin-Dependent Kinase Inhibitor p27
- Drug Administration Schedule
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Enzyme Activation -- drug effects
- Enzyme Precursors -- metabolism
- Flavonoids -- administration & dosage
- Gene Deletion
- Genes, p53
- Growth Inhibitors -- administration & dosage
- Humans
- In Situ Hybridization, Fluorescence
- Interleukin-4 -- pharmacology
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microtubule-Associated Proteins -- biosynthesis
- Neoplasm Proteins -- biosynthesis
- Piperidines -- administration & dosage
- Proto-Oncogene Proteins -- biosynthesis
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- physiology
- Tumor Suppressor Proteins
- Vidarabine -- analogs & derivatives
- bcl-2-Associated X Protein
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Publication Type: Journal Article
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