An antibody from a patient with ranitidine-induced thrombocytopenia recognizes a site on glycoprotein IX that is a favored target for drug-induced antibodies. [electronic resource]
Producer: 19981019Description: 2359-65 p. digitalISSN:- 0006-4971
- Aged
- Animals
- Anti-Ulcer Agents -- adverse effects
- Antibodies, Monoclonal -- immunology
- Antibody Specificity
- Antigen-Antibody Reactions
- Autoantibodies -- immunology
- Autoimmune Diseases -- chemically induced
- Blood Platelets -- immunology
- CHO Cells
- Cimetidine -- chemistry
- Cricetinae
- Cricetulus
- Epitopes -- immunology
- Famotidine -- chemistry
- Female
- Flow Cytometry
- Histamine H2 Antagonists -- adverse effects
- Humans
- Molecular Structure
- Nizatidine -- chemistry
- Platelet Glycoprotein GPIb-IX Complex -- chemistry
- Precipitin Tests
- Protein Conformation
- Quinidine -- adverse effects
- Quinine -- adverse effects
- Ranitidine -- adverse effects
- Recombinant Fusion Proteins -- immunology
- Structure-Activity Relationship
- Thrombocytopenia -- chemically induced
- Transfection
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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