Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and rapamycin. [electronic resource]
Producer: 19980825Description: 627-38 p. digitalISSN:- 0002-9440
- Animals
- B-Lymphocytes -- immunology
- CD8-Positive T-Lymphocytes -- immunology
- Cyclosporine -- administration & dosage
- Drug Therapy, Combination
- Endothelium, Vascular -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Flow Cytometry
- Genes, MHC Class II -- physiology
- Graft Rejection -- immunology
- Humans
- Immunosuppressive Agents -- administration & dosage
- Keratinocytes -- metabolism
- Mice
- Mice, SCID
- Microcirculation -- drug effects
- Polyenes -- administration & dosage
- Sirolimus
- Skin -- blood supply
- Skin Transplantation -- immunology
- T-Lymphocytes -- immunology
- Transplantation, Homologous
- Vascular Cell Adhesion Molecule-1 -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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