Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines. [electronic resource]
Producer: 19980611Description: 5355-65 p. digitalISSN:- 0022-1767
- Animals
- Bone Marrow Transplantation -- immunology
- CD4-Positive T-Lymphocytes -- metabolism
- CD8-Positive T-Lymphocytes -- transplantation
- Cell Separation
- Cytokines -- biosynthesis
- Cytotoxicity, Immunologic -- drug effects
- Female
- Graft vs Host Disease -- immunology
- Histocompatibility Antigens Class II -- genetics
- Immunosuppressive Agents -- administration & dosage
- Injections, Intraperitoneal
- Leukemia, Myeloid, Acute -- immunology
- Lymphocyte Activation -- drug effects
- Lymphocyte Transfusion
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Polyenes -- administration & dosage
- Radiation Chimera
- Receptors, Antigen, T-Cell, alpha-beta
- Sirolimus
- T-Lymphocyte Subsets -- metabolism
- Th1 Cells -- immunology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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