Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. [electronic resource]
Producer: 19980608Description: 16-28 p. digitalISSN:- 0003-9861
- Anti-Inflammatory Agents, Non-Steroidal -- metabolism
- Aryl Hydrocarbon Hydroxylases
- Chromatography, DEAE-Cellulose
- Chromatography, Ion Exchange
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 Enzyme System -- isolation & purification
- Electrophoresis, Polyacrylamide Gel
- Humans
- Hydroxylation
- Kinetics
- Mephenytoin -- pharmacokinetics
- Microsomes, Liver -- enzymology
- Mixed Function Oxygenases -- isolation & purification
- Omeprazole -- pharmacokinetics
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- isolation & purification
- Substrate Specificity
- Tolbutamide -- pharmacokinetics
- Ultrafiltration
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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