Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. [electronic resource]
Producer: 19980223Description: 2910-6 p. digitalISSN:- 0021-9258
- Apoptosis -- drug effects
- Caspase 3
- Caspase 6
- Caspase 7
- Caspases
- Cysteine Endopeptidases -- drug effects
- Enzyme Activation -- drug effects
- Humans
- Jurkat Cells
- Lamin Type B
- Lamins
- Lysophospholipids
- Models, Biological
- Nuclear Proteins -- metabolism
- Poly Adenosine Diphosphate Ribose -- metabolism
- Signal Transduction
- Sphingosine -- analogs & derivatives
- T-Lymphocytes -- drug effects
- Tetradecanoylphorbol Acetate -- pharmacology
- fas Receptor -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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