Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. [electronic resource]
Producer: 19980213Description: 4372-7 p. digitalISSN:- 0022-2623
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- 3',5'-Cyclic-GMP Phosphodiesterases -- antagonists & inhibitors
- Administration, Oral
- Animals
- Antihypertensive Agents -- chemical synthesis
- Blood Pressure -- drug effects
- Cyclic AMP -- metabolism
- Cyclic GMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 1
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Magnetic Resonance Spectroscopy
- Molecular Structure
- Phosphodiesterase Inhibitors -- chemical synthesis
- Phosphoric Diester Hydrolases
- Polycyclic Compounds -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Rats
- Structure-Activity Relationship
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Publication Type: Journal Article
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