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  2. Details for: Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
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Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. [electronic resource]

By:
  • Xia, Y
Contributor(s):
  • Chackalamannil, S
  • Czarniecki, M
  • Tsai, H
  • Vaccaro, H
  • Cleven, R
  • Cook, J
  • Fawzi, A
  • Watkins, R
  • Zhang, H
Producer: 19980213Description: 4372-7 p. digitalISSN:
  • 0022-2623
Subject(s):
  • 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
  • 3',5'-Cyclic-GMP Phosphodiesterases -- antagonists & inhibitors
  • Administration, Oral
  • Animals
  • Antihypertensive Agents -- chemical synthesis
  • Blood Pressure -- drug effects
  • Cyclic AMP -- metabolism
  • Cyclic GMP -- metabolism
  • Cyclic Nucleotide Phosphodiesterases, Type 1
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phosphodiesterase Inhibitors -- chemical synthesis
  • Phosphoric Diester Hydrolases
  • Polycyclic Compounds -- chemical synthesis
  • Pyrimidines -- chemical synthesis
  • Rats
  • Structure-Activity Relationship
Online resources:
  • Available from publisher's website
In: Journal of medicinal chemistry vol. 40
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Publication Type: Journal Article

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Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.

APA

Xia Y., Chackalamannil S., Czarniecki M., Tsai H., Vaccaro H., Cleven R., Cook J., Fawzi A., Watkins R. & Zhang H. (19980213). Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. : Journal of medicinal chemistry.

Chicago

Xia Y, Chackalamannil S, Czarniecki M, Tsai H, Vaccaro H, Cleven R, Cook J, Fawzi A, Watkins R and Zhang H. 19980213. Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. : Journal of medicinal chemistry.

Harvard

Xia Y., Chackalamannil S., Czarniecki M., Tsai H., Vaccaro H., Cleven R., Cook J., Fawzi A., Watkins R. and Zhang H. (19980213). Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. : Journal of medicinal chemistry.

MLA

Xia Y, Chackalamannil S, Czarniecki M, Tsai H, Vaccaro H, Cleven R, Cook J, Fawzi A, Watkins R and Zhang H. Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. : Journal of medicinal chemistry. 19980213.

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