Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). [electronic resource]
Producer: 19980210Description: 1899-910 p. digitalISSN:- 0888-8809
- Animals
- Carcinoma, Hepatocellular
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Activation -- drug effects
- Humans
- Insulin -- pharmacology
- Insulin Receptor Substrate Proteins
- Intracellular Signaling Peptides and Proteins
- Liver Neoplasms
- Organometallic Compounds -- pharmacology
- Phenanthrolines -- pharmacology
- Phosphatidylinositol 3-Kinases -- drug effects
- Phosphoproteins -- drug effects
- Phosphorylation -- drug effects
- Precipitin Tests
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases -- antagonists & inhibitors
- Rats
- Receptor, Insulin -- antagonists & inhibitors
- Recombinant Fusion Proteins
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- Signal Transduction -- drug effects
- Substrate Specificity -- drug effects
- Tumor Cells, Cultured
- Tyrosine -- metabolism
- src Homology Domains -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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