Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin. [electronic resource]
Producer: 19980107Description: 17-30 p. digitalISSN:- 0009-2797
- Antibiotics, Antitubercular -- metabolism
- Antitubercular Agents -- metabolism
- Cytochrome P-450 Enzyme System -- biosynthesis
- Drug Evaluation, Preclinical -- methods
- Enzyme Induction -- drug effects
- Glucuronates -- metabolism
- Humans
- Hydroxylation
- Isoenzymes -- biosynthesis
- Liver -- cytology
- Rifabutin -- metabolism
- Rifampin -- analogs & derivatives
- Structure-Activity Relationship
- Testosterone -- metabolism
- Time Factors
- Zidovudine -- metabolism
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Publication Type: Comparative Study; Journal Article
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