Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. [electronic resource]
Producer: 19971208Description: 307-11 p. digitalISSN:- 0014-5793
- 3-Phosphoinositide-Dependent Protein Kinases
- Alanine
- Amino Acid Sequence
- Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors
- Cell Line
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Humans
- Insulin -- pharmacology
- Insulin-Like Growth Factor I -- pharmacology
- Isoenzymes -- metabolism
- Mutagenesis, Site-Directed
- Phosphoprotein Phosphatases -- metabolism
- Phosphorylation
- Phosphoserine -- metabolism
- Phosphotyrosine -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Recombinant Proteins -- antagonists & inhibitors
- Serine
- Transfection
- Tyrosine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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