From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors. [electronic resource]
Producer: 19971230Description: 73-8 p. digitalISSN:- 0065-2598
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Carrageenan -- toxicity
- Chromium Radioisotopes
- Cyclooxygenase 1
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- chemical synthesis
- Digestive System -- drug effects
- Edema -- chemically induced
- Feces -- chemistry
- Fever -- chemically induced
- Indomethacin -- analogs & derivatives
- Isoenzymes -- drug effects
- Membrane Proteins
- Molecular Conformation
- Molecular Structure
- Neoplasm Proteins -- antagonists & inhibitors
- Prostaglandin-Endoperoxide Synthases -- drug effects
- Rats
- Structure-Activity Relationship
- Substrate Specificity
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article
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