CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients. [electronic resource]
Producer: 19970930Description: 571-6 p. digitalISSN:- 0041-1337
- Animals
- Body Weight
- Bone Marrow Transplantation -- adverse effects
- CD4-Positive T-Lymphocytes -- physiology
- CD8-Positive T-Lymphocytes -- physiology
- Graft vs Host Disease -- etiology
- Histocompatibility Antigens Class II -- radiation effects
- Major Histocompatibility Complex -- physiology
- Membrane Glycoproteins -- deficiency
- Mice
- Mice, Inbred C57BL
- Perforin
- Pore Forming Cytotoxic Proteins
- Spleen -- cytology
- Survival Rate
- Whole-Body Irradiation
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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