Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. [electronic resource]
Producer: 19970902Description: 211-21 p. digitalISSN:- 0960-314X
- 7-Alkoxycoumarin O-Dealkylase -- metabolism
- Alleles
- Antineoplastic Agents, Alkylating -- metabolism
- Aryl Hydrocarbon Hydroxylases
- Blotting, Western
- Catalysis
- Cyclophosphamide -- metabolism
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System -- genetics
- Humans
- Hydroxylation
- Ifosfamide -- metabolism
- In Vitro Techniques
- Kinetics
- Mixed Function Oxygenases -- genetics
- Phosphatidylcholines -- metabolism
- Polymorphism, Genetic
- Structure-Activity Relationship
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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