DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. [electronic resource]
Producer: 19970724Description: 4070-9 p. digitalISSN:- 0270-7306
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Core Binding Factor Alpha 2 Subunit
- DNA Fragmentation -- drug effects
- DNA-Binding Proteins -- genetics
- Enzyme Inhibitors -- adverse effects
- Etoposide -- pharmacology
- Histone-Lysine N-Methyltransferase
- Humans
- Mice
- Myeloid-Lymphoid Leukemia Protein
- Proto-Oncogene Proteins
- Proto-Oncogenes
- Restriction Mapping
- Species Specificity
- Topoisomerase II Inhibitors
- Transcription Factors -- genetics
- Translocation, Genetic
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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