Effect of subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on immune system and target gene responses in mice: calculation of benchmark doses for CYP1A1 and CYP1A2 related enzyme activities. [electronic resource]
Producer: 19970821Description: 372-82 p. digitalISSN:- 0340-5761
- Animals
- Aryl Hydrocarbon Hydroxylases
- Body Weight -- drug effects
- Cell Count -- drug effects
- Cytochrome P-450 CYP1A1 -- metabolism
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP1B1
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation, Enzymologic -- drug effects
- Injections, Intraperitoneal
- Interleukin-1 -- genetics
- Liver -- drug effects
- Lung -- drug effects
- Mice
- Mice, Inbred C57BL
- Organ Size -- drug effects
- Polychlorinated Dibenzodioxins -- administration & dosage
- Polymerase Chain Reaction
- RNA, Messenger -- biosynthesis
- Regression Analysis
- Thymus Gland -- cytology
- Transforming Growth Factor alpha -- genetics
- Transforming Growth Factor beta -- genetics
- Tumor Necrosis Factor-alpha -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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