Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells. [electronic resource]
Producer: 19970708Description: 645-51 p. digitalISSN:- 0264-6021
- Animals
- Calcium -- metabolism
- Cell Membrane Permeability -- drug effects
- Digitonin -- pharmacology
- Estrenes -- pharmacology
- Inositol 1,4,5-Trisphosphate -- physiology
- Intracellular Fluid -- metabolism
- Ion Channel Gating -- drug effects
- Ion Channels -- drug effects
- Islets of Langerhans -- drug effects
- Male
- Mice
- Mice, Inbred Strains
- Patch-Clamp Techniques
- Phosphatidylinositol Diacylglycerol-Lyase
- Phosphodiesterase Inhibitors -- pharmacology
- Pyrrolidinones -- pharmacology
- Second Messenger Systems -- physiology
- Type C Phospholipases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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