Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. [electronic resource]
Producer: 19970610Description: 4212-22 p. digitalISSN:- 0270-6474
- Alzheimer Disease -- genetics
- Amyloid beta-Peptides -- pharmacology
- Animals
- Antioxidants -- pharmacology
- Apoptosis -- drug effects
- Blood Proteins -- pharmacology
- Calcium -- metabolism
- Dantrolene -- pharmacology
- Endoplasmic Reticulum -- physiology
- Enzyme Inhibitors -- pharmacology
- Fura-2
- Homeostasis -- physiology
- Humans
- Membrane Proteins -- genetics
- Muscle Relaxants, Central -- pharmacology
- Mutation -- physiology
- Nerve Growth Factors -- pharmacology
- Neurons -- drug effects
- Oxidative Stress -- physiology
- PC12 Cells -- cytology
- Presenilin-1
- Proto-Oncogene Proteins c-bcl-2 -- physiology
- Rats
- Reactive Oxygen Species -- metabolism
- Thapsigargin -- pharmacology
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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