MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis. [electronic resource]
Producer: 19970424Description: 3189-96 p. digitalISSN:- 0022-1767
- Antibodies, Monoclonal -- metabolism
- Apoptosis -- immunology
- Benzoquinones
- Cell Division -- immunology
- Enzyme Activation -- immunology
- HLA Antigens -- metabolism
- Histocompatibility Antigens Class I -- metabolism
- Humans
- Immunophenotyping
- Jurkat Cells
- Lactams, Macrocyclic
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Membrane Proteins -- classification
- Molecular Weight
- Phosphorylation
- Protein-Tyrosine Kinases -- metabolism
- Quinones -- toxicity
- Receptor-CD3 Complex, Antigen, T-Cell -- immunology
- Receptors, Antigen, T-Cell -- classification
- Rifabutin -- analogs & derivatives
- T-Lymphocytes -- metabolism
- ZAP-70 Protein-Tyrosine Kinase
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article
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