Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. [electronic resource]
Producer: 19970521Description: 11336-43 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Ankyrin Repeat
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Compartmentation
- Cell Nucleus -- metabolism
- Conserved Sequence
- DNA-Binding Proteins -- genetics
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Leukemia-Lymphoma, Adult T-Cell -- etiology
- Membrane Proteins -- genetics
- Nuclear Proteins
- Oncogene Proteins -- genetics
- Peptide Fragments -- genetics
- Promoter Regions, Genetic
- Receptor, Notch1
- Receptors, Cell Surface
- Sequence Deletion
- T-Lymphocytes -- cytology
- Transcription Factors -- genetics
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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