Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors. [electronic resource]
Producer: 19970417Description: 1028-34 p. digitalISSN:- 0007-0920
- Alkynes
- Antineoplastic Agents, Alkylating -- pharmacology
- Cell Cycle -- drug effects
- Cell Survival -- drug effects
- DNA, Neoplasm -- biosynthesis
- Deoxyadenosines -- pharmacology
- Diamines -- pharmacology
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Ornithine Decarboxylase Inhibitors
- Ovarian Neoplasms
- Polyamines -- metabolism
- Spermine -- metabolism
- Topoisomerase II Inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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