Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein. [electronic resource]
Producer: 19970414Description: 6457-64 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Arginine
- Collagen -- chemistry
- Computer Simulation
- Cysteine
- Exostoses, Multiple Hereditary -- genetics
- Humans
- Macromolecular Substances
- Microscopy, Electron
- Molecular Sequence Data
- Osteoarthritis -- genetics
- Point Mutation
- Protein Binding
- Protein Denaturation
- Protein Structure, Tertiary
- Structure-Activity Relationship
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Publication Type: Journal Article
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