Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. [electronic resource]
Producer: 19970304Description: 309-20 p. digitalISSN:- 0890-9369
- Alleles
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases -- metabolism
- Embryo, Mammalian -- abnormalities
- Enhancer Elements, Genetic
- Enzyme Activation
- ErbB Receptors -- genetics
- Female
- Fetal Death
- Fibroblasts
- Gene Deletion
- Gene Targeting
- Genes, Dominant
- Guanine Nucleotide Exchange Factors
- Heart Defects, Congenital -- embryology
- Hematopoietic Stem Cells
- Heterozygote
- Male
- Mice
- Mice, Inbred C57BL
- Mutagenesis
- Phenotype
- Proteins -- genetics
- Signal Transduction
- Stem Cells
- ras Guanine Nucleotide Exchange Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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