Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. [electronic resource]
Producer: 19970310Description: 146-56 p. digitalISSN:- 1061-4036
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal -- biosynthesis
- Antibody Affinity
- Antibody Diversity
- Antibody Formation
- B-Lymphocytes -- cytology
- Chromosomes, Artificial, Yeast -- genetics
- ErbB Receptors -- immunology
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Hybridomas -- immunology
- Immunoglobulin Heavy Chains -- biosynthesis
- Immunoglobulin kappa-Chains -- biosynthesis
- Interleukin-8 -- immunology
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Molecular Sequence Data
- Species Specificity
- Transgenes
- Tumor Necrosis Factor-alpha -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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