Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity. [electronic resource]
Producer: 19970317Description: 1230-9 p. digitalISSN:- 0893-228X
- Animals
- Biotransformation
- Chromatography, High Pressure Liquid
- DNA Repair
- Dogs
- Free Radical Scavengers -- chemistry
- Gas Chromatography-Mass Spectrometry
- Haplorhini
- Humans
- In Vitro Techniques
- Male
- Microsomes, Liver -- metabolism
- Mutagens -- chemistry
- Protein Binding
- Pyrimidines -- chemistry
- Pyrroles -- chemistry
- Rats
- Rats, Inbred F344
- Spectrometry, Mass, Fast Atom Bombardment
- Spectrophotometry, Ultraviolet
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Publication Type: Journal Article
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