Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. [electronic resource]
Producer: 19970212Description: 932-9 p. digitalISSN:- 0090-9556
- Analgesics, Opioid -- metabolism
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Fentanyl -- analogs & derivatives
- Gas Chromatography-Mass Spectrometry
- Humans
- Ketoconazole -- pharmacology
- Kinetics
- Microsomes, Liver -- enzymology
- Mixed Function Oxygenases -- antagonists & inhibitors
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- metabolism
- Theophylline -- analogs & derivatives
- Tolbutamide -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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