Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans. [electronic resource]
Producer: 19970311Description: 839-51 p. digitalISSN:- 0049-8254
- Animals
- Benzophenones -- blood
- Catechol O-Methyltransferase Inhibitors
- Cells, Cultured
- Dogs
- Enzyme Inhibitors -- pharmacokinetics
- Humans
- Liver -- cytology
- Male
- Metabolic Clearance Rate
- Models, Biological
- Nitrophenols
- Pharmacokinetics
- Predictive Value of Tests
- Rabbits
- Rats
- Rats, Inbred Strains
- Species Specificity
- Time Factors
- Tolcapone
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Publication Type: Journal Article
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