Human estrogen receptor ligand activity inversion mutants: receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens. [electronic resource]
Producer: 19970501Description: 230-42 p. digitalISSN:- 0888-8809
- 3T3 Cells -- drug effects
- Animals
- Breast Neoplasms -- pathology
- CHO Cells -- drug effects
- Cricetinae
- Cricetulus
- Estradiol -- analogs & derivatives
- Estrogen Antagonists -- classification
- Estrogens -- metabolism
- Female
- Humans
- Ligands
- Mice
- Neoplasms, Hormone-Dependent -- pathology
- Point Mutation
- Polyunsaturated Alkamides
- Promoter Regions, Genetic
- Protein Binding
- Receptors, Estrogen -- drug effects
- Recombinant Fusion Proteins -- biosynthesis
- Structure-Activity Relationship
- Substrate Specificity
- Tamoxifen -- analogs & derivatives
- Transcription, Genetic
- Tumor Cells, Cultured -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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