The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. [electronic resource]
Producer: 19961209Description: 905-15 p. digitalISSN:- 0969-2126
- Amino Acid Sequence
- Antineoplastic Agents -- chemistry
- Binding Sites -- drug effects
- Catalysis
- Crystallography, X-Ray
- Drug Design
- Enzyme Inhibitors -- chemistry
- Estradiol -- chemistry
- Estradiol Dehydrogenases -- antagonists & inhibitors
- Estrone -- metabolism
- Female
- Humans
- Macromolecular Substances
- Models, Molecular
- Molecular Conformation
- Molecular Sequence Data
- NADP -- chemistry
- Oxidation-Reduction
- Oxygen -- chemistry
- Placenta -- enzymology
- Protein Binding -- drug effects
- Protein Conformation
- Recombinant Proteins -- chemistry
- Serine -- chemistry
- Substrate Specificity
- Temperature
- Tyrosine -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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