The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. [electronic resource]
Producer: 19960715Description: 6470-82 p. digitalISSN:- 0006-2960
- Amyloid -- chemistry
- Amyloidosis -- genetics
- Animals
- Escherichia coli -- genetics
- Humans
- Hydrogen-Ion Concentration
- Models, Molecular
- Molecular Structure
- Mutagenesis, Site-Directed
- Prealbumin -- chemistry
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Protein Structure, Tertiary
- Recombinant Proteins -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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