Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant. [electronic resource]
Producer: 19960715Description: 5670-8 p. digitalISSN:- 0006-2960
- Amino Acid Sequence
- Binding Sites -- genetics
- Coenzymes -- metabolism
- Drug Design
- Escherichia coli -- enzymology
- Isocitrate Dehydrogenase -- chemistry
- Kinetics
- Models, Molecular
- Molecular Conformation
- Molecular Sequence Data
- Molecular Structure
- NAD -- chemistry
- NADP -- metabolism
- Point Mutation
- Protein Conformation
- Protein Engineering
- Sequence Homology, Amino Acid
- Substrate Specificity
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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