The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma. [electronic resource]
Producer: 19960621Description: 2151-63 p. digitalISSN:- 0270-7306
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Drosophila Proteins
- Glutathione Transferase -- biosynthesis
- HeLa Cells
- Humans
- Isoenzymes -- metabolism
- Kinetics
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Oncogene Proteins -- biosynthesis
- Phenylalanine
- Phosphopeptides -- chemistry
- Phosphorylation
- Protein-Tyrosine Kinases -- biosynthesis
- Proto-Oncogene Proteins -- biosynthesis
- Proto-Oncogene Proteins c-ret
- Proto-Oncogenes
- Receptor Protein-Tyrosine Kinases -- biosynthesis
- Recombinant Fusion Proteins -- biosynthesis
- Transfection
- Type C Phospholipases -- metabolism
- Tyrosine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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