The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties. [electronic resource]
Producer: 19960314Description: 1044-8 p. digitalISSN:- 0027-8424
- Acute Disease
- Animals
- Blast Crisis
- Calcium-Calmodulin-Dependent Protein Kinases -- biosynthesis
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Chimera
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 3
- Core Binding Factor Alpha 2 Subunit
- DNA-Binding Proteins
- Glycogen Synthase Kinase 3
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- genetics
- Leukemia, Myeloid -- genetics
- Mice
- Myelodysplastic Syndromes -- genetics
- Neoplasm Proteins -- biosynthesis
- Proto-Oncogene Proteins
- RNA-Binding Proteins -- biosynthesis
- Rats
- Receptor, Macrophage Colony-Stimulating Factor -- biosynthesis
- Recombinant Fusion Proteins -- biosynthesis
- Recombinant Proteins -- biosynthesis
- Ribosomal Proteins
- Transcription Factors -- biosynthesis
- Transfection
- Translocation, Genetic
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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