Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcription factors. Both HNF-4 and C/EBP beta are required for liver-specific activity of the ornithine transcarbamylase enhancer. [electronic resource]
Producer: 19940222Description: 1323-31 p. digitalISSN:- 0021-9258
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- CHO Cells
- Cricetinae
- DNA Primers -- chemistry
- DNA-Binding Proteins -- physiology
- Enhancer Elements, Genetic
- Female
- Gene Expression Regulation, Enzymologic
- Hepatocyte Nuclear Factor 4
- Liver -- enzymology
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Nuclear Proteins -- physiology
- Ornithine Carbamoyltransferase -- genetics
- Phosphoproteins
- Promoter Regions, Genetic
- Sequence Deletion
- Structure-Activity Relationship
- Tissue Distribution
- Transcription Factors -- physiology
- Transcription, Genetic
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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