Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase activation. [electronic resource]
Producer: 19940404Description: 6729-34 p. digitalISSN:- 0021-9258
- Actins -- blood
- Adult
- Cell Membrane -- metabolism
- Cytoskeleton -- metabolism
- GTP-Binding Proteins -- isolation & purification
- Granulomatous Disease, Chronic -- blood
- Humans
- In Vitro Techniques
- NADH, NADPH Oxidoreductases -- blood
- NADPH Dehydrogenase -- isolation & purification
- NADPH Oxidases
- Neutrophils -- drug effects
- Phosphoproteins -- isolation & purification
- Superoxides -- blood
- Tetradecanoylphorbol Acetate -- pharmacology
- rac GTP-Binding Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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